diff --git a/Modules/Internal/CMakeCUDAArchitecturesValidate.cmake b/Modules/Internal/CMakeCUDAArchitecturesValidate.cmake
index 57dd7e370a..3f4d15ab6a 100644
--- a/Modules/Internal/CMakeCUDAArchitecturesValidate.cmake
+++ b/Modules/Internal/CMakeCUDAArchitecturesValidate.cmake
@@ -5,6 +5,11 @@ function(cmake_cuda_architectures_validate lang)
   if(DEFINED CMAKE_${lang}_ARCHITECTURES)
     if(CMAKE_${lang}_ARCHITECTURES STREQUAL "")
       message(FATAL_ERROR "CMAKE_${lang}_ARCHITECTURES must be non-empty if set.")
+    elseif(CMAKE_${lang}_ARCHITECTURES MATCHES [["]])
+      message(FATAL_ERROR
+        "CMAKE_${lang}_ARCHITECTURES contains literal quotes:\n"
+        "  ${CMAKE_${lang}_ARCHITECTURES}\n"
+      )
     elseif(CMAKE_${lang}_ARCHITECTURES AND NOT CMAKE_${lang}_ARCHITECTURES MATCHES "^([0-9]+(a|f)?(-real|-virtual)?(;[0-9]+(a|f)?(-real|-virtual)?|;)*|all|all-major|native)$")
       message(FATAL_ERROR
         "CMAKE_${lang}_ARCHITECTURES:\n"
diff --git a/Tests/RunCMake/CUDA_architectures/RunCMakeTest.cmake b/Tests/RunCMake/CUDA_architectures/RunCMakeTest.cmake
index 3e6b3a5517..7f0611a18f 100644
--- a/Tests/RunCMake/CUDA_architectures/RunCMakeTest.cmake
+++ b/Tests/RunCMake/CUDA_architectures/RunCMakeTest.cmake
@@ -5,6 +5,7 @@ run_cmake(architectures-all-major)
 run_cmake(architectures-native)
 run_cmake(architectures-empty)
 run_cmake(architectures-invalid)
+run_cmake(architectures-quotes)
 
 run_cmake(architectures-not-set)
 include("${RunCMake_BINARY_DIR}/architectures-not-set-build/info.cmake" OPTIONAL)
diff --git a/Tests/RunCMake/CUDA_architectures/architectures-quotes-result.txt b/Tests/RunCMake/CUDA_architectures/architectures-quotes-result.txt
new file mode 100644
index 0000000000..d00491fd7e
--- /dev/null
+++ b/Tests/RunCMake/CUDA_architectures/architectures-quotes-result.txt
@@ -0,0 +1 @@
+1
diff --git a/Tests/RunCMake/CUDA_architectures/architectures-quotes-stderr.txt b/Tests/RunCMake/CUDA_architectures/architectures-quotes-stderr.txt
new file mode 100644
index 0000000000..79e16fbbe2
--- /dev/null
+++ b/Tests/RunCMake/CUDA_architectures/architectures-quotes-stderr.txt
@@ -0,0 +1,10 @@
+^CMake Error at .*/Internal/CMakeCUDAArchitecturesValidate\.cmake:[0-9]+ \(message\):
+  CMAKE_CUDA_ARCHITECTURES contains literal quotes:
+
+    "all-major"
+
+Call Stack \(most recent call first\):
+  [^
+]*/Modules/CMakeDetermineCUDACompiler.cmake:[0-9]+ \(cmake_cuda_architectures_validate\)
+  architectures-quotes\.cmake:2 \(enable_language\)
+  CMakeLists\.txt:3 \(include\)$
diff --git a/Tests/RunCMake/CUDA_architectures/architectures-quotes.cmake b/Tests/RunCMake/CUDA_architectures/architectures-quotes.cmake
new file mode 100644
index 0000000000..fbdc7ce3d8
--- /dev/null
+++ b/Tests/RunCMake/CUDA_architectures/architectures-quotes.cmake
@@ -0,0 +1,2 @@
+set(CMAKE_CUDA_ARCHITECTURES "\"all-major\"")
+enable_language(CUDA)