diff --git a/Modules/Compiler/GNU-ASM.cmake b/Modules/Compiler/GNU-ASM.cmake
index 3daa57d13f..94af401da5 100644
--- a/Modules/Compiler/GNU-ASM.cmake
+++ b/Modules/Compiler/GNU-ASM.cmake
@@ -9,4 +9,5 @@ if(CMAKE_ASM${ASM_DIALECT}_COMPILER_ID_VENDOR_MATCH STREQUAL "GNU assembler")
   set(CMAKE_DEPFILE_FLAGS_ASM${ASM_DIALECT} "--MD <DEPFILE>")
   set(CMAKE_ASM${ASM_DIALECT}_LINK_EXECUTABLE
     "<CMAKE_LINKER> <FLAGS> <CMAKE_ASM${ASM_DIALECT}_LINK_FLAGS> <LINK_FLAGS> <OBJECTS> -o <TARGET> <LINK_LIBRARIES>")
+  set(CMAKE_ASM_DEFINE_FLAG "--defsym ")
 endif()
diff --git a/Tests/RunCMake/BuildDepends/GNU-AS.cmake b/Tests/RunCMake/BuildDepends/GNU-AS.cmake
index 21921ef18b..0c7249a0cc 100644
--- a/Tests/RunCMake/BuildDepends/GNU-AS.cmake
+++ b/Tests/RunCMake/BuildDepends/GNU-AS.cmake
@@ -5,6 +5,7 @@ message(STATUS "CMAKE_ASM${ASM_DIALECT}_COMPILER_ID_VENDOR_MATCH='${CMAKE_ASM${A
 
 add_library(gnu_as STATIC gnu_as.s)
 target_include_directories(gnu_as PRIVATE ${CMAKE_CURRENT_BINARY_DIR})
+target_compile_definitions(gnu_as PRIVATE "TEST_DEF=Hello")
 
 file(GENERATE OUTPUT ${CMAKE_CURRENT_BINARY_DIR}/check-$<LOWER_CASE:$<CONFIG>>.cmake CONTENT "
 set(check_pairs