diff --git a/Source/cmVisualStudio10TargetGenerator.cxx b/Source/cmVisualStudio10TargetGenerator.cxx
index 23a726a1a2..3cd9c62d1f 100644
--- a/Source/cmVisualStudio10TargetGenerator.cxx
+++ b/Source/cmVisualStudio10TargetGenerator.cxx
@@ -3765,7 +3765,7 @@ void cmVisualStudio10TargetGenerator::WriteClOptions(
 
     // Specify the compiler program database file if configured.
     std::string pdb = this->GeneratorTarget->GetCompilePDBPath(configName);
-    if (!pdb.empty()) {
+    if (!pdb.empty() && !cmHasSuffix(pdb, '/') && !cmHasSuffix(pdb, '\\')) {
       if (this->GlobalGenerator->IsCudaEnabled()) {
         // CUDA does not quote paths with spaces correctly when forwarding
         // this to the host compiler.  Use a relative path to avoid spaces.