diff --git a/changelog/unreleased/configure-grpc-in-ocs.md b/changelog/unreleased/configure-grpc-in-ocs.md
new file mode 100644
index 000000000..1b6011ef6
--- /dev/null
+++ b/changelog/unreleased/configure-grpc-in-ocs.md
@@ -0,0 +1,5 @@
+Enhancement: Configure GRPC in ocs
+
+Fixes a panic in ocs when running not in single binary
+
+https://github.com/owncloud/ocis/pull/6022
diff --git a/services/ocs/pkg/command/server.go b/services/ocs/pkg/command/server.go
index 7c3b6c989..0abd76bdb 100644
--- a/services/ocs/pkg/command/server.go
+++ b/services/ocs/pkg/command/server.go
@@ -11,6 +11,7 @@ import (
 	"github.com/owncloud/ocis/v2/services/ocs/pkg/tracing"
 
 	"github.com/oklog/run"
+	ogrpc "github.com/owncloud/ocis/v2/ocis-pkg/service/grpc"
 	"github.com/owncloud/ocis/v2/services/ocs/pkg/config"
 	"github.com/owncloud/ocis/v2/services/ocs/pkg/metrics"
 	"github.com/owncloud/ocis/v2/services/ocs/pkg/server/debug"
@@ -34,6 +35,11 @@ func Server(cfg *config.Config) *cli.Command {
 				return err
 			}
 
+			err = ogrpc.Configure(ogrpc.GetClientOptions(cfg.GRPCClientTLS)...)
+			if err != nil {
+				return err
+			}
+
 			var (
 				gr          = run.Group{}
 				ctx, cancel = func() (context.Context, context.CancelFunc) {
diff --git a/services/ocs/pkg/config/config.go b/services/ocs/pkg/config/config.go
index c492fc8a5..1ee40a4c2 100644
--- a/services/ocs/pkg/config/config.go
+++ b/services/ocs/pkg/config/config.go
@@ -19,6 +19,8 @@ type Config struct {
 
 	HTTP HTTP `yaml:"http"`
 
+	GRPCClientTLS *shared.GRPCClientTLS `yaml:"grpc_client_tls"`
+
 	TokenManager *TokenManager `yaml:"token_manager"`
 
 	Context context.Context `yaml:"-"`
diff --git a/services/ocs/pkg/config/defaults/defaultconfig.go b/services/ocs/pkg/config/defaults/defaultconfig.go
index a8796ff24..223ccefcb 100644
--- a/services/ocs/pkg/config/defaults/defaultconfig.go
+++ b/services/ocs/pkg/config/defaults/defaultconfig.go
@@ -3,6 +3,7 @@ package defaults
 import (
 	"strings"
 
+	"github.com/owncloud/ocis/v2/ocis-pkg/structs"
 	"github.com/owncloud/ocis/v2/services/ocs/pkg/config"
 )
 
@@ -86,6 +87,10 @@ func EnsureDefaults(cfg *config.Config) {
 	if cfg.Commons != nil {
 		cfg.HTTP.TLS = cfg.Commons.HTTPServiceTLS
 	}
+
+	if cfg.GRPCClientTLS == nil && cfg.Commons != nil {
+		cfg.GRPCClientTLS = structs.CopyOrZeroValue(cfg.Commons.GRPCClientTLS)
+	}
 }
 
 // Sanitize sanitizes the configuration