diff --git a/pre_commit/clientlib.py b/pre_commit/clientlib.py
index 7fb49d78..c04cf333 100644
--- a/pre_commit/clientlib.py
+++ b/pre_commit/clientlib.py
@@ -130,6 +130,7 @@ CONFIG_SCHEMA = schema.Map(
     'Config', None,
 
     schema.RequiredRecurse('repos', schema.Array(CONFIG_REPO_DICT)),
+    schema.Optional('exclude', schema.check_regex, '^$'),
     schema.Optional('fail_fast', schema.check_bool, False),
 )
 
diff --git a/pre_commit/commands/run.py b/pre_commit/commands/run.py
index e260b662..6f695487 100644
--- a/pre_commit/commands/run.py
+++ b/pre_commit/commands/run.py
@@ -183,6 +183,7 @@ def _run_hooks(config, repo_hooks, args, environ):
     skips = _get_skips(environ)
     cols = _compute_cols([hook for _, hook in repo_hooks], args.verbose)
     filenames = _all_filenames(args)
+    filenames = _filter_by_include_exclude(filenames, '', config['exclude'])
     retval = 0
     for repo, hook in repo_hooks:
         retval |= _run_single_hook(filenames, hook, repo, args, skips, cols)
diff --git a/tests/commands/run_test.py b/tests/commands/run_test.py
index 46d2a7e1..51e4eac9 100644
--- a/tests/commands/run_test.py
+++ b/tests/commands/run_test.py
@@ -183,6 +183,21 @@ def test_exclude_types_hook_repository(
         assert b'exe' not in printed
 
 
+def test_global_exclude(cap_out, tempdir_factory, mock_out_store_directory):
+    git_path = make_consuming_repo(tempdir_factory, 'script_hooks_repo')
+    with cwd(git_path):
+        with modify_config() as config:
+            config['exclude'] = '^foo.py$'
+        open('foo.py', 'a').close()
+        open('bar.py', 'a').close()
+        cmd_output('git', 'add', '.')
+        ret, printed = _do_run(cap_out, git_path, _get_opts(verbose=True))
+        assert ret == 0
+        # Does not contain foo.py since it was excluded
+        expected = b'hookid: bash_hook\n\nbar.py\nHello World\n\n'
+        assert printed.endswith(expected)
+
+
 def test_show_diff_on_failure(
         capfd, cap_out, tempdir_factory, mock_out_store_directory,
 ):